huntington's disease — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8452	Dantrolene		Others
	Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.		Others
T9998	MIND4-19		Sirtuin
	MIND4-19 is an inhibitor of SIRT2 with antitumor activity.		Sirtuin
T6111	Selisistat	EX-527,SEN0014196	Sirtuin
	Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM). Selisistat can be used in the study of neurological disorders such as Huntington's chorea.		Sirtuin
T9159	PBT-1033	PB 1033,PBT1033,PBT-2,PBT 2,PBT2	Others
	PBT-1033 (PBT-2) is a potential neuroprotective agent for the treatment of Alzheimer's disease and Huntington's disease.		Others
T22595	B2	Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline	Others , Sirtuin
	B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease		Others , Sirtuin
T62839	Dalzanemdor	SAGE-718	NMDAR , iGluR
	Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dysfunction.		NMDAR , iGluR
T61859	MK-28		Antiviral , PERK
	MK-28 is a selective PERK agonist that reduces toxicity and prolongs survival in a Huntington's disease model.MK-28 has a significant killing effect on MK28 gastric cancer cells.		Antiviral , PERK
T23331	SC 51089	SC 51089 free base	Prostaglandin Receptor
	SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's...		Prostaglandin Receptor
T38605	NCT-504		Others
	NCT-504, a selective allosteric inhibitor of PIP4Kγ, exhibits an IC50 value of 15.8 μM. It holds promise for the investigation of Huntington's disease.		Others
T2075	Pyrazolo[1,5-a]pyrimidine 4h		Others
	Pyrazolo[1,5-a]pyrimidine 4h is a morpholine derivative that is a selective antagonist of the adenosine A2A receptor. It has been shown to be neuroprotective in animal models of Parkinson's disease and Huntington's chore...		Others
T9340	1-phenyl-3,4-dihydroisochinoline	3,4-Dihydro-1-phenylisoquinoline	Others
	1-phenyl-3,4-dihydroisochinoline (3,4-Dihydro-1-phenylisoquinoline) is a structural analog of the neurotransmitter dopamine that interacts with dopamine receptors in the central nervous system. It has been studied as a p...		Others
T13133	Tetrabenazine Metabolite	(-)-β-Dihydrotetrabenazine,(-)-β-HTBZ	Monoamine Transporter
	Tetrabenazine Metabolite ((-)-β-HTBZ), a vesicles monoamine transporter 2 (VMAT2) inhibitor, is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite has a high affinity for VMAT2 with a Ki of 13.4 nM. Tetraben...		Monoamine Transporter
T40652	Meclizine	Meclozine	Histamine Receptor
	Meclizine, also known as Meclozine, is a piperazine class H1 antagonist with antihistamine properties that inhibits the interaction of histamine at H1 receptors reversibly. It serves as an effective anti-motion sickness ...		Histamine Receptor
T33895	PBT-1033 hydrochloride	PBT 1033,PBT2,PBT 2,PBT-2,PBT1033,PBT-1033
	PBT-1033 hydrochloride is a potential neuroprotective agent for the treatment of Alzheimer's disease and Huntington's disease.
T28363	PF-02545920
	PF-02545920, a PDE10 inhibitor, is used potentially for the treatment of Huntington's Disease.
T39480	Lexanersen	WVE-120102,Lexanersen
	Lexanersen (WVE-120102), an antisense oligonucleotide, is utilized in Huntington's disease research.
T40843	1-(Anilinocarbonyl)proline
	1-(Anilinocarbonyl)proline is a compound utilized for identifying dual-action probes within a cell model of Huntington's disease.
T69441	NSC66098
	NSC66098 is a novel potent inhibitor of Huntington's disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein.
T71969	Remacemide
	Remacemide is a low-affinity NMDA antagonist with sodium channel blocking properties. It has been studied for the treatment of acute ischemic stroke, epilepsy, Huntington's disease, and Parkinson's disease.
T34662	SMER10	SMER-10,SMER 10
	SMER10 is an enhancer of the clearance of mutant aggregate-prone proteins by autophagy in mammalian cell models of Huntington's and Parkinson's disease, independent of rapamycin.